A large percentage of people with MS do not suffer severe disabilities associated with their condition. Often, they live their lives with a "manageable disability", such as a limp or bladder control problems. One of the most common adjustments to lifestyle is learning to plan ahead or allow for a flexible schedule in case symptoms change without warning. For instance, it is often necessary to allow for rest periods during the day when fatigue becomes a problem. Multiple sclerosis patients are encouraged to be pro-active in maintaining active lifestyles. This can be done through exercise, a controlled diet, job planning and anticipating changes within the family and other relationships.

Regular exercise or physiotherapy can help many MS patients keep as fit as possible. Lack of exercise often leads to shortening of muscles; decreased bone density, which leads to an increased risk of fractures; and shallow, inefficient breathing. Depending on active symptoms, exercise may not be possible at all times. A doctor can help develop an exercise program specific to each individual. Many patients find yoga, swimming and horseback riding to be excellent forms of exercise. While not all patients will be able to participate in these activities, any exercise can be beneficial in maintaining muscle tone, reducing stress and promoting relaxation. Many patients also reap the social benefits of exercise, as these are often group activities.

Diet can also play a role in optimizing a healthy lifestyle for people with MS. While there is no evidence that a poor diet causes MS, there is evidence to support that a proper diet can alleviate some symptoms of MS. Patients are often recommended to follow a diet low in animal fat and high in fiber as a part of managing their symptoms.

Job planning may be necessary for patients who are experiencing debilitating symptoms. Some patients, however, may continue their employment with no substantial interruptions. There is no legal obligation to disclose the diagnosis of MS to an employer, however some patients choose to if their job performances will be affected. Some options to consider are flextime and modified equipment such as a special telephone. The Americans with Disabilities Act (ADA) requires employers to provide reasonable accommodations and offers other provisions to protect employees diagnosed with MS.

Family changes are inevitable, as MS affects the entire household as well as relationships the patient has with others. The stress of living with this condition is often shared by all members of the family or household and must be dealt with accordingly. The diagnosis often leads to a disruption of routines. Family counseling can alleviate some of the strains of dealing with MS and the subsequent changes in routine. Children especially need to be informed about what to expect when a member of the family or household is diagnosed. Hiding information will only exacerbate the stress further down the line.

Every case of multiple sclerosis is unique to the individual and every person handles it in a unique way. It may take time to adjust to the changes that are often necessary to live life with MS, but with support, time and patience, the majority of patients are able to live active, fulfilling lives.